Werner Seeger Selected Research

Enzymes

1/2022	Myeloid-cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice.
12/2021	Hypercapnia Induces Inositol-Requiring Enzyme 1α-Driven Endoplasmic Reticulum-associated Degradation of the Na,K-ATPase β-Subunit.
2/2020	Hypercapnia Impairs Na,K-ATPase Function by Inducing Endoplasmic Reticulum Retention of the β-Subunit of the Enzyme in Alveolar Epithelial Cells.
1/2020	Isoform-specific characterization of class I histone deacetylases and their therapeutic modulation in pulmonary hypertension.
5/2019	Exhalative Breath Markers Do Not Offer for Diagnosis of Interstitial Lung Diseases: Data from the European IPF Registry (eurIPFreg) and Biobank.
6/2015	Collagen and elastin cross-linking is altered during aberrant late lung development associated with hyperoxia.
7/2014	Lysyl oxidases play a causal role in vascular remodeling in clinical and experimental pulmonary arterial hypertension.
6/2010	HIF-1 alpha signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells.
1/2008	Functional role and species-specific contribution of arginases in pulmonary fibrosis.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Werner Seeger Research Topics

Disease

118	Pulmonary Hypertension 04/2024 - 01/2002
84	Hypoxia (Hypoxemia) 04/2024 - 01/2002
67	Pulmonary Arterial Hypertension 05/2024 - 04/2002
46	Neoplasms (Cancer) 04/2024 - 03/2004
43	Fibrosis (Cirrhosis) 04/2024 - 09/2002
38	Vascular Remodeling 04/2024 - 04/2004
26	Idiopathic Pulmonary Fibrosis 11/2022 - 12/2007
25	Inflammation (Inflammations) 04/2024 - 06/2002
25	Lung Neoplasms (Lung Cancer) 01/2023 - 09/2006
24	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2023 - 12/2003
19	Familial Primary Pulmonary Hypertension 05/2024 - 05/2002
19	Lung Injury 04/2024 - 01/2004
19	Pneumonia (Pneumonitis) 01/2023 - 06/2002
18	Lung Diseases (Lung Disease) 10/2023 - 09/2004
18	Acute Lung Injury 08/2023 - 02/2007
18	Edema (Dropsy) 01/2023 - 03/2003
17	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2023 - 12/2003
16	Hyperoxia 10/2023 - 02/2007
16	Infections 01/2023 - 03/2003
15	Chronic Obstructive Pulmonary Disease (COPD) 11/2023 - 10/2008
15	Bronchopulmonary Dysplasia 10/2023 - 02/2007
13	Emphysema 11/2023 - 10/2011
13	Cardiomegaly (Heart Hypertrophy) 01/2023 - 01/2004
12	Heart Failure 10/2023 - 01/2015
11	Interstitial Lung Diseases (Interstitial Lung Disease) 10/2019 - 07/2002
10	Neoplasm Metastasis (Metastasis) 02/2022 - 03/2010
10	Right Ventricular Hypertrophy 01/2021 - 01/2010
10	Hypertrophy 01/2021 - 08/2007
10	Sepsis (Septicemia) 07/2014 - 06/2002
8	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2023 - 10/2009
8	Hypercapnia 12/2021 - 02/2008
8	Critical Illness (Critically Ill) 06/2020 - 03/2006
7	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 01/2002
6	Ventricular Remodeling 01/2023 - 02/2012
6	Body Weight (Weight, Body) 12/2018 - 12/2003
5	Adenocarcinoma of Lung 01/2023 - 01/2009
5	Respiratory Insufficiency (Respiratory Failure) 01/2023 - 02/2004
5	COVID-19 06/2022 - 01/2020
5	Hypertension (High Blood Pressure) 12/2020 - 03/2006
5	Dyspnea (Shortness of Breath) 11/2020 - 08/2002
5	Hyperplasia 11/2014 - 05/2008

Drug/Important Bio-Agent (IBA)

41	Proteins (Proteins, Gene)FDA Link 01/2023 - 02/2004
29	MonocrotalineIBA 01/2023 - 01/2004
26	Oxygen (Dioxygen)IBA 10/2023 - 01/2002
25	Bleomycin (Blenoxane)FDA LinkGeneric 04/2024 - 12/2003
23	Iloprost (Ventavis)FDA Link 01/2022 - 01/2002
21	CytokinesIBA 01/2023 - 06/2002
21	Sildenafil Citrate (Viagra)FDA Link 01/2018 - 04/2002
17	Biomarkers (Surrogate Marker)IBA 10/2023 - 04/2008
15	Surface-Active Agents (Surfactants)IBA 01/2023 - 01/2004
15	CollagenIBA 12/2022 - 12/2003
13	LipidsIBA 06/2020 - 05/2002
13	ProstaglandinsIBA 12/2018 - 06/2002
12	SmokeIBA 04/2024 - 10/2011
12	Transcription Factors (Transcription Factor)IBA 01/2022 - 10/2002
12	treprostinil FDA Link 03/2017 - 01/2006
11	Small Interfering RNA (siRNA)IBA 02/2024 - 05/2005
11	NADPH Oxidases (NAD(P)H oxidase)IBA 07/2020 - 05/2004
11	EmulsionsIBA 06/2020 - 05/2002
11	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 09/2002
11	Messenger RNA (mRNA)IBA 01/2019 - 03/2002
11	Epoprostenol (Prostacyclin)FDA LinkGeneric 10/2011 - 04/2002
9	Matrix Metalloproteinases (MMPs)IBA 01/2023 - 09/2009
9	EnzymesIBA 01/2022 - 01/2008
9	Semaxinib (SU5416)IBA 01/2022 - 09/2008
9	Superoxides (Superoxide)IBA 01/2020 - 12/2003
9	Soluble Guanylyl CyclaseIBA 01/2018 - 01/2006
9	AerosolsIBA 04/2017 - 12/2003
9	Fish OilsIBA 05/2015 - 05/2002
9	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2015 - 11/2002
8	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2023 - 12/2003
8	Adenosine Triphosphatases (ATPase)IBA 12/2021 - 10/2005
8	LipopolysaccharidesIBA 06/2018 - 06/2002
8	Phosphodiesterase 5 InhibitorsIBA 01/2018 - 01/2004
8	ThromboxanesIBA 02/2011 - 05/2002
7	Vasodilator Agents (Vasodilators)IBA 09/2021 - 01/2002
7	Pulmonary Surfactants (Pulmonary Surfactant)IBA 01/2021 - 01/2004
7	Arachidonic Acid (Vitamin F)IBA 01/2018 - 05/2002
7	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidIBA 02/2011 - 12/2003
6	RNA (Ribonucleic Acid)IBA 04/2024 - 08/2017
6	AntioxidantsIBA 01/2023 - 01/2004
6	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2022 - 02/2007
6	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022 - 04/2011
6	pirfenidoneIBA 11/2020 - 01/2015
6	Protein Isoforms (Isoforms)IBA 11/2020 - 04/2006
6	Fatty Acids (Saturated Fatty Acids)IBA 06/2020 - 05/2002
6	Omega-6 Fatty Acids (Omega 6 Fatty Acids)IBA 06/2020 - 05/2002
6	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2019 - 05/2002
6	LigandsIBA 01/2017 - 11/2007
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2014 - 06/2002
6	Imatinib Mesylate (Gleevec)FDA Link 01/2013 - 09/2005
6	Vasoconstrictor AgentsIBA 10/2007 - 05/2002
5	Histones (Histone)IBA 01/2021 - 07/2015
5	riociguatIBA 01/2019 - 03/2010
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2018 - 01/2002

Therapy/Procedure

65	Therapeutics 07/2023 - 04/2002
7	Parenteral Nutrition 06/2020 - 05/2003
6	Lung Transplantation 04/2021 - 01/2004
5	Immunomodulation 06/2020 - 02/2007
5	Lasers (Laser) 10/2015 - 09/2005